Identifikasi Kerusakan Sel pada Hepar dan Ren Tikus Putih (Rattus norvegicus, L.) Jantan Setelah diberi Pakan Mie Berboraks selama 30 Hari Berturut-Turut

Abstract

This descriptive research is aimed to identify cell damaged on liver and kidney of Male White Rat ( Rattus norvegicus L ) after given of noodle contained borax in 30 consecutive days. 25 of male white rats were used as sample which were grouped into 5 treatment as followed P0 (control, given 100% pellet), P1 (given 25% noodle contained borax and 75% pellet), P2 (given 50% noodle contained borax and 50% pellet), P3 (given 75% noodle contained borax and 25% pellet) and P4 (given 100% noodle contained borax). After being treated with noodle contained borax in 30 consecutive days, all rats were dissected to take out the liver and kidney, then all organs were micro technically processed and stained with HE. Furthermore, all preparation were observed carefully under the microscope to see if some damaged cells occurred. The result shows that there were some damaged cells either in liver cells or kidney cells in the form of cloudy swelling (P1 and P2), fatty acid degeneration (P2 and P3), and necrotic in P4. So, it can be concluded that consuming noodle contained borax in 30 consecutive days for male white rat ( Rattus norvegicus, L ) will cause cloudy swelling, fatty acid degeneration and necrotic in liver and kidney cells.