Sensitivity Comparison Between Erythromycin and Chloramphenicol on the Bacteria Salmonella sp

Abstract

Salmonella sp. is a digestive pathogenic microbe that potentially causes death. The illness that cause by Salmonella sp. infection. is treated with antibiotic therapy. wich thas potentiall temerges problem called antibiotic resistanc. The problem is driven by the misuse of antibiotic therefore appropriate use of antibiotic is needed. This study was carried out to determine the sensitivity of Salmonella sp. bacteria towards two kinds of antibiotic with different dosage namely erythromycin 250mg / mL and 500mg/mL and chloramphenicol 250mg/mL and 500mg/mL with 3 replications. The study was conducted by using Kirby-Bauer method (disk diffusion test). Salmonella sp. bacteria was suspended in Brain Heart Infusion Broth (BHIB) media and antibiotic tests were carried out with Mueller Hinton agar (MHA) media. The greatest inhibition power was shown by Chloramphenicol 500 mg/mL with 38.6 mm inhibition zone. The following high sensitivity was depicted in the treatment of Chloramphenicol 250 mg/mL with 33.33 mm inhibition zone whereas both of Erythromycin dosages exhibited only intermediate and weak ability in inhibiting Salmonella sp. growth.